Maternal nutrition and fetal imprinting of the male progeny.

The global population as well as the demand for human food is rapidly growing worldwide, which necessitates improvement of efficiency in livestock operations. In this context, environmental factors during fetal and/or neonatal life have been observed to influence normal physical and physiological function of an individual during adulthood, and this phenomenon is called fetal or developmental programming. While numerous studies have reported the impact of maternal factors on development of the female progeny, limited information is available on the potential effects of fetal programming on reproductive function of the male offspring. Therefore, the objective for this review article was to focus on available literature regarding the impact of maternal factors, particularly maternal nutrition, on reproductive system of the male offspring. To this end, we highlighted developmental programming of the male offspring in domestic species (i.e., pig, cow and sheep) as well as laboratory species (i.e., mice and rat) during pregnancy and lactation. In this sense, we pointed out the effects of maternal nutrition on various functions of the male offspring including hypothalamic-pituitary axis, hormonal levels, testicular tissue and semen parameters.

Effects of concomitant exposure to styrene and intense noise on rats' whole lung tissues. Biochemical and histopathological studies.

Concurrent exposure to styrene (ST) and noise is common especially in industrial environments. The present study aims to determine the related oxidant-induced changes as the result of combined exposure to ST and noise. For this purpose, 24 male Wistar rats were used in four experimental groups (n = 6/groups): (1) control group, (2) the group exposed to an octave band of noise centered at 8 kHz (100 dB SPL) (6 h/day), (3) the group inhalationally exposed to ST (750 ppm) (6 h/day), (4) the group exposed to noise and ST simultaneously. The DNA damage was measured by assessing the concentration of 8-hydroxyl-2-deoxyguanosine (8-OHdG) using ELISA kit. Levels of lipid peroxidation (MDA), GSH and antioxidative activity of SOD and CAT were also determined in whole lung tissues. The results relatively indicated that sub-acute exposure to both noise and ST can lead to pathological damage in rat lung tissues. Furthermore, enhanced levels of 8-OHdG and MDA production were observed in lung tissues. In contrast, GSH, CAT and SOD were markedly reduced in co-exposed group. The results of the study verified additive interaction between noise and ST on accumulation of DNA oxidation products, progressive morphological damages as well as undermining the antioxidative defense system in the rat lung tissues.